Biotutkimukseen ja diagnostiikkaan

Sisältöön
MCE:n  (MedChem Express) valikoima käsittää laajan valikoiman biokemikaaleja, joihin kuuluu yli 50 000 bioaktiivista yhdistettä, värjäysreagensseja, peptidejä ja luonnontuotteiden kemiallisia yhdisteitä.                                                         
Nyt myös oligonukleotidejä ja geenejä.


Viimeisimpiä julkaisuja, joissa käytetty MCE:n tuotteita




            

Nature.
2022 Dec;612(7940):555-563.

Science.
2022 Dec 2;378(6623):eabo5503.

Cell.
2022 Nov 10;185(23):4347-4360.e17.

Cell.
2022 Dec 8;185(25):4801-4810.e13.
UUSIA TUOTTEITA


CAS No.: 129830-38-2
                                                    
Y-27632 dihydrochloride GMP
                                                                 
Research Area: ROCK       Inhibitor/Cell Therapy
                                                               
Y-27632 dihydrochloride was produced by using GMP guidelines.
An orally active and ATP-competitive ROCK inhibitor.
Induces fibroblasts to convert into pluripotent stem  cells (hiPSCs).
_______________________________________________                                                                              
                
CAS No.: 1630936-95-6
                                          
VU0422288
                                                                 
Research Area: mGluR       Modulator
                                
A group III mGlu receptor positive allosteric modulator  with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7,  and mGluR8, respectively.
Shows selectivity over a panel of 68 other GPCRs, ion  channels and transporters.
Potentiates mGlu7-mediated reductions in excitatory post  synaptic potentials.
                                                                
Solubility: DMSO : 25 mg/mL (69.41 mM; Need ultrasonic)
              
_______________________________________________
                
CAS No.: 1425945-63-6
                                          
EHT 5372
                                                                 
Research Area: DYRK       Inhibitor
                                                                     
A highly potent and selective inhibitor of DYRK’s family kinases.
Dose-dependently reduces pS396-Tau levels.
Reduces Aβ production in a dose-dependent reduction.
                                                                
Solubility: DMSO     : 6.67 mg/mL (16.50 mM; ultrasonic and warming and heat to 60°C)
              
_______________________________________________
                
CAS No.: 2763260-39-3
                                          
NRX-252114
                                                                 
Research Area: Molecular       Glue
                                
A potent enhancer of the interaction between β-catenin,  and its cognate E3 ligase, SCFβ-TrCP.
Further enhances the ubiquitylation of pSer33/S37A  β-catenin peptide to form long ubiquitin chains.
Potentiates the ubiquitylation of unphosphorylated  Ser33/S37A β-catenin peptides.
                                                                
Solubility: DMSO : 100 mg/mL (195.96 mM; Need ultrasonic)
              
_______________________________________________
                
CAS No.: 1814881-70-3
                                          
LEM-14
                                                                                    
Research Area: NSD2 Inhibitor
                                                
The first NSD2 specific inhibitor.
A hit inhibitor with an in vitro IC50 of 132 μM  against H3K36 methylation by NSD2.
                                                                
Solubility: DMSO     : 50 mg/mL (104.48 mM; Need ultrasonic)
              
Bio-Mediator
Linnaistentie 5
01640 Vantaa

Puh. 040 562 9574
www.bio.fi
info(at)bio.fi
tilaukset(at)bio.fi

www.labshop.fi
www.elektrokem.fi  
©
Bio-Mediator on
Elektrokem Oy:n aputoiminimi
www.elektrokem.fi
Takaisin sisältöön