MCE:n (MedChem Express) valikoima käsittää laajan valikoiman biokemikaaleja, joihin kuuluu yli 50 000 bioaktiivista yhdistettä, värjäysreagensseja, peptidejä ja luonnontuotteiden kemiallisia yhdisteitä.
Nyt myös oligonukleotidejä ja geenejä.
Viimeisimpiä julkaisuja, joissa käytetty MCE:n tuotteita
Nature.
2022 Dec;612(7940):555-563.
Science.
2022 Dec 2;378(6623):eabo5503.
Cell.
2022 Nov 10;185(23):4347-4360.e17.
Cell.
2022 Dec 8;185(25):4801-4810.e13.
2022 Dec;612(7940):555-563.
Science.
2022 Dec 2;378(6623):eabo5503.
Cell.
2022 Nov 10;185(23):4347-4360.e17.
Cell.
2022 Dec 8;185(25):4801-4810.e13.
UUSIA TUOTTEITA
CAS No.: 129830-38-2
Y-27632 dihydrochloride GMP
Research Area: ROCK Inhibitor/Cell Therapy
• Y-27632 dihydrochloride was produced by using GMP guidelines.
• An orally active and ATP-competitive ROCK inhibitor.
• Induces fibroblasts to convert into pluripotent stem cells (hiPSCs).
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CAS No.: 1630936-95-6
VU0422288
Research Area: mGluR Modulator
• A group III mGlu receptor positive allosteric modulator with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively.
• Shows selectivity over a panel of 68 other GPCRs, ion channels and transporters.
• Potentiates mGlu7-mediated reductions in excitatory post synaptic potentials.
Solubility: DMSO : 25 mg/mL (69.41 mM; Need ultrasonic)
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CAS No.: 1425945-63-6
EHT 5372
Research Area: DYRK Inhibitor
• A highly potent and selective inhibitor of DYRK’s family kinases.
• Dose-dependently reduces pS396-Tau levels.
• Reduces Aβ production in a dose-dependent reduction.
Solubility: DMSO : 6.67 mg/mL (16.50 mM; ultrasonic and warming and heat to 60°C)
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CAS No.: 2763260-39-3
NRX-252114
Research Area: Molecular Glue
• A potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP.
• Further enhances the ubiquitylation of pSer33/S37A β-catenin peptide to form long ubiquitin chains.
• Potentiates the ubiquitylation of unphosphorylated Ser33/S37A β-catenin peptides.
Solubility: DMSO : 100 mg/mL (195.96 mM; Need ultrasonic)
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CAS No.: 1814881-70-3
LEM-14
Research Area: NSD2 Inhibitor
• The first NSD2 specific inhibitor.
• A hit inhibitor with an in vitro IC50 of 132 μM against H3K36 methylation by NSD2.
Solubility: DMSO : 50 mg/mL (104.48 mM; Need ultrasonic)